The Effect of Vitamin D Level on Blood Glucose, HbA1c and Some Inflammatory Markers in Patients with Type 2 Diabetes Mellitus

Nisreen  Ali; Nouralsalhin Alaagib; Abdalla Abdelatif; Osama Ali; Walli Elmagbol; Sameer Alhojaily; Ibrahim Albokhadaim; Saad Shousha; Ahmed Alameen

doi:10.54548/njps.v39i2.5

Autori

Nisreen Ali Pediatric Neurology Unit, Pediatric Department, Al - Sabah Hospital, Kuwait
Nouralsalhin Alaagib Sulaiman Alrajhi University, Al Qassim- Al Bukayriyah, , PO Box 777, Saudi Arabia.
Abdalla Abdelatif 2- Department of Physiology, Faculty of Veterinary Medicine, University of Khartoum. PO Box: 32, Postal code: 13314 Shambat, Khartoum North, Sudan.
Osama Ali 2- Department of Physiology, Faculty of Veterinary Medicine, University of Khartoum. PO Box: 32, Postal code: 13314 Shambat, Khartoum North, Sudan.
Walli Elmagbol
Sameer Alhojaily Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Saudi Arabia, P.O. Box 400 Al-Ahsa 31982, Saudi Arabia.
Ibrahim Albokhadaim 3- Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Saudi Arabia, P.O. Box 400 Al-Ahsa 31982, Saudi Arabia.
Saad Shousha 4Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Saudi Arabia, P.O. Box 400 Al-Ahsa 31982, Saudi Arabia.
Ahmed Alameen 1- Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, 31982 Al-Ahsa, Saudi Arabia.

DOI:

https://doi.org/10.54548/njps.v39i2.5

Rezumat

Diabetes problems are more likely to occur in people with low vitamin D levels. In this study, Sudanese individuals diagnosed with type 2 diabetes mellitus (T2DM) had their serum glucose, HbA1c, vitamin D, and inflammatory markers assessed. Thirty men and thirty women who had been diagnosed with T2DM for at least two years were among the 120 participants of both sexes, ages 35 to 69, who were enrolled in this case-control study. As a control group, the second group consisted of sixty healthy individuals (30 men and 30 women). Every participant had a thorough medical history taken, with special attention to the length of their diabetes, its medical history, and any previous problems. During the clinical examination and laboratory tests, the following criteria were evaluated: total WBC, ESR, CRP, HbA1c, and serum vitamin D3. When 25(OH) vitamin D3 levels were utilized to assess T2DM patients, they showed significantly lower mean blood concentrations than controls: 23 (38.3%) had vitamin D insufficiency, 23 (38.3%) had vitamin D deficiency, and 14 (23.3%) had sufficient vitamin D. Vitamin D-deficient patients had significant increases in HbA1c, glucose, CRP, and total WBC. Additionally, when comparing the mean ESR values of diabetes patients to those of the control group, there is a statistically significant rise. ESR did not significantly alter depending on the controlling level. Males also had a numerically higher level of vitamin D3 than females. Compared to healthy normal controls, individuals with type 2 diabetes have noticeably reduced vitamin D3 levels. Furthermore, in T2DM patients, there was a connection between elevated inflammatory markers and HbA1c and insufficiency in vitamin D.

Referințe

Dr F Carbone, Department of Cardiology, Foundation for Medical research, University of Geneva, Avenue de la Roseraie 64, 1211 Geneva, Switzerland. e.mail:frederico.carbone@unige.ch

Dr Mohammed Hadi Abdulla, Department of Physiology, University College Cork, Cork, Ireland, e.mail: mdapharm78@yahoo.co.uk), + 353 21 420 5866

Dr. Haseeb Anwar, PhD, Department of Physiology, Government College University, Faisalabad, Pakistan. Email: hasib_1@hotmail.com

The Effect of Vitamin D Level on Blood Glucose, HbA1c and Some Inflammatory Markers in Patients with Type 2 Diabetes Mellitus

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