Tóm tắt
As a contribution to the on-going search for alternative, available and affordable treatment of common infections in Sub-saharan Africa, the efficacy of local herbs, Senna alata(Linn) and Borreria
ocymoides(Burm), in comparison with conventional drugs, griseofulvin and clotrimazole in the treatment of dermatophytosis among primary school children, was examined in the three districts of Cross River State, South-South Nigeria. Out of 840 pupils screened, 68(8.1%) were infected, with incidence ranging from 11(1.3%) in the southern to 33(3.9%) in the northern districts, indicating a widespread of the infection. Specimens taken from the infected pupils and analyzed for the causative agents, showed that Trichophyton tonsurans 29(20.4%) followed by Microsporum soudanense 24(16.9%) was most frequent. The greater sensitivity of the isolated dermatophytes to the local plants than the chemotherapeutic drugs (control) offers some hope of treatment and control. The antifungal activity of the plants was associated with their very high levels of chemical components, saponins, anthraquinones and flavonoids. We recommend further studies on the chemical properties and safety of the plants before total dependence on them for treatment.
Keywords: Dermatophytosis, primary school children, herbal therapy, Senna alata, Borreria ocymoides, South-south Nigeria.
Résumé
Pour contribuer à la recherche d’un traitement alternative, disponible et moins cher contre les infections communes au sud du Sahara en Afrique. L’efficacité des herbes médicinales locales senna Alata(Linn) et Borreria Ocynoides(Burn) en comparant les médicaments conventionnels ; griséofulvine et clotrimazole dans le traitement des dermatophytoses parmi les enfants de l’école primaires était examine dans les districts de l’état du River dans le sud-sud du Nigeria. Hors des 840 écoliers testes,68 (8.1%) étaient infectes avec une incidence variante de 11(1.3%) au sud a 33(3.9%) aux districts du Nord indiquant la distribution de l’infection. Les échantillons obtenues des écoliers et analysées montraient que les trichophytons tousurane 29(20.4%), suivi de microspore soudanaise 24(16.9%) étant le plus fréquent. La sensitivité la plus élevée des dermatophytes isolées des plantes locales que les agents chimiothérapeutiques (contrôle) offre des espoirs pour de traitement et contrôle de ces infections. L’activité antifongique de ces plantes était associée avec leurs niveaux plus élevés des substances chimiques, anthraquinones et flavonoïdes. Nous avons recommande que des études approfondies sur les propriétés chimique, les tests d’efficace et de toxicité de ces plantes soient faite avant leur indication thérapeutique.
Correspondence: Dr. M.E. Eja, Department of Biological Sciences, Cross River University of Technology, PMB 1123, Calabar, Nigeria. E-mail: mattheweja2000@yahoo.com
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