Abstract
Introduction: Cerebral atrophy is a common accompaniment of ageing and several neurological conditions. Magnetic Resonance Imaging (MRI) was used to compare brain volumes of stroke survivors with stroke-free controls in this first report from sub-Saharan Africa.
Methods: Participants comprised 45 stroke patients and 54 stroke–free controls. Structural brain MR images were acquired from participants and volumes of grey, white matters and CSF extracted.
Results: The % of white matter in Intracranial Volume (ICV)(stroke:0.45±0.03, control: 0.47±0.03, p=0.02) and the % of total brain volume in ICV (stroke:0.85±0.03, control: 0.87±0.02, p=0.002) were
significantly greater in the controls than stroke patients.The % of CSF in ICV (stroke:0.15±0.03, control:0.13±0.03, p=0.002) was significantly smaller in the controls than the stroke patients. The
controls (68.9±10.0 years, p<0.001) were significantly older than the stroke (59.8±11.0 years) subjects. When adjusted for age, the % of white matter in ICV (male:0.44±0.03, female:0.46±0.04, p=0.043) was significantly less in male than female in the stroke group.
Conclusions: Our results showed that stroke patients develop greater brain atrophy compared to controls. We also found that male stroke patients had greater white matter atrophy than their female counterparts. These findings may have implications for cognitive functions in stroke patients.
Keywords: Africa, Brain atrophy, MRI, Stroke
Résumé
Contexte: L’atrophie cérébrale est un accompagnement fréquent du vieillissement et de nombreuses conditions neurologiques. L’imagerie par résonance magnétique (IRM) a été utilisée pour comparer les volumes cérébraux de survivants d’attaque paralytique avec des témoins sans d’attaque paralytique dans ce premier rapport de l’Afrique subsaharienne.
Méthodes: Les participants comprenaient 45 patients avec attaque paralytique et 54 témoins sans attaque paralytique. Des imagesstructurelles parRM du cerveau ont été acquises provenant des participants et les volumes de matières grises, blanches et de CSF ont été extraits.
Résultats: Le pourcentage de substance blanche dans le volume intracrânien (VIC) (attaque paralytique: 0,45 ± 0,03, témoin: 0,47 ± 0,03, p = 0,02) et lepourcentagedu volume cérébral total dans VIC (attaque paralytique: 0,85 ± 0,03, témoin: 0,87 ± 0,02, p = 0,002) étaient significativement plus grands chez les témoins que chez les patients ayant subi uneattaque paralytique. Le pourcentage de CSF dans le VIC (attaque paralytique: 0,15 ± 0,03, témoin: 0,13 ± 0,03, p = 0,002) était significativement plus faible chez les témoins que chez les patients ayant subi uneattaque paralytique. Les témoins (68,9 ± 10,0 ans, p <0,001) étaient significativement plus âgés que les sujets ayant subi uneattaque paralytique (59,8 ± 11,0 ans). Une fois ajusté pour l’âge, le pourcentage de substance blanche dans le VIC (homme: 0,44 ± 0,03, femme: 0,46 ± 0,04, p = 0,043) était significativement moins élevé chez les hommes que chez les femmes dans le groupe ayant subi uneattaque paralytique.
Conclusions: Nos résultats ont montré que les patients ayant subi uneattaque paralytique développent une atrophie cérébrale plus importante que les témoins. Nous avons également constaté que les hommesayant subi uneattaque paralytiqueavaient une atrophie de la substance blanche plus importante que leurs homologues féminins. Ces résultats peuvent avoir des implications pour les fonctions cognitives chez les patients ayant subi uneattaque paralytique.
Mots-clés: Afrique, Atrophie cérébrale, IRM, attaque paralytique
Correspondence: Prof. B.S. Aribisala, Department of Computer Science, Lagos State University, Ojoo, Lagos, Nigeria. E-mail:benjaminaribisala@lasu.edu.ng
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