Abstract
Background: The human foetus receives a passive
immunization by selective passage across the placenta
of maternal gamma immunoglobulin (IgG) by
attaching to the constant fraction of neonatal receptor
(FcRn) which is a specific IgG transporter. Two of
the patients assayed hypothyroid had postpartum
haemorrhage (PPH), incidentally also had very low
mean thyroid hormone level which should normally
increase in pregnancy.
Rationale/Aim: A probable relationship of
immunoglobulin density (IgGp) of mothers, their
thyroid hormone levels and postpartum haemorrhage
was evaluated for possible clinical intervention.
Methodology: Twenty pregnant women were
presented at our antenatal clinics and qualified for
the inclusion criteria consented freely to participate
in the investigation. Ex-vivo placental models of
different thyroid states, as well as maternal blood
from the antecubital vein and umblical cord blood
(mixed blood) were taken within five minutes
postpartum. The trafficking of IgG was investigated
by immunohistochemical staining and pulse-chased
at 370C at neutral pH. Maternal thyroid hormone
levels were also evaluated.
Results: The IgG in two hypothyroid cases with post
partum haemorrhage was significantly (P<0.001)
deficient in the sera and (P<0.01) in the other
hypothyroids that had no PPH when compared with
euthyroid mothers.
Conclusion: The thyroid hormone level of the mother
suggests to be an obvious natural determinant of the
passive immunization of the neonate and possible
occurrence of post partum haemorrhage.
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