Abstrak
Background: Albizia adianthifolia (Mimosoideae) is a medicinal plant used in the management of infections and central nervous system disorders. The presented study evaluated the antidepressant properties of the ethanol extract of Albizia adianthifolia leaves (EEAAL) in mice.
Methods: Pulverised leaves of Albizia adianthifolia were extracted with 50% ethanol by cold maceration and concentrated to dryness. Swiss mice were divided into five groups and treated with distilled water (10 mL/kg), EEAAL (1.25, 2.50, 5.00 mg/kg, i.p.) and imipramine (12 mg/kg). Antidepressant activity was assessed by force swim test (FST), tail suspension test (TST), reserpine-induced depression model and yohimbine-induced lethality test. Open field paradigm was used to screen the false results in FST and TST.
Results: The EEAAL (1.25, 2.50 mg/kg) significantly reduced immobility time in FST at dose 1.25 mg/kg (40.8 ± 13.1) and 2.50 mg/kg (42.4 ± 9.7) compared to control (170.0 ± 10.1) [p<0.05]. Similarly, 1.25 mg/kg of the extract significantly reduced immobility time in TST (85.2 ± 8.9) compared to control (142.6 ± 3.9) [p<0.05] without causing changes in spontaneous motor activity in open field. EEAAL reversed diarrhoea, ptosis, and hypothermia induced by reserpine compared with control groups and did not potentiate yohimbine-induced lethality.
Conclusion: It was concluded that the extract has antidepressant like properties which supports its ethnomedicinal use in the treatment of depression.
Keywords: Immobility, antidepressant, Albizia adiantifolia, imipramine, reserpine
Résumé
Contexte: Albizia adianthifolia (Mimosoideae) est une plante médicinale utilisée dans la gestion des infections, et des troubles du système nerveux central. L’étude présentée a évalué les propriétés antidépressives de l’extrait à l’éthanol des feuilles d’Albizia adianthifolia (EEFAA) chez les souris.
Méthodes:Des feuillespulvérisées d’Albizia adianthifoliaont été extraites avec de l’éthanol à 50% par macération froide et concentrées à sec.Des souris suisses ont été divisées en cinq groupes et traitées avec de l’eau distillée (10 ml / kg), de l’EEFAA(1,25 ; 2,50; 5,00 mg / kg,i.p.) et de l’imipramine (12 mg / kg).L’activité antidépressive a été évaluée par le test de nage à force (TNF), le test de suspension de la queue (TSQ), modèle de dépression induite par la réserpine et le test de létalité induite par layohimbine.Le paradigme du champ ouvert a été utilisé pour filtrer les faux résultats dans TNF et TSQ.
Résultats : L’EEFAA (1,25 ; 2,50 mg / kg) a significativement réduit le temps d’immobilité dans le TNF à la dose de 1,25 mg / kg (40,8 ± 13,1) et de 2,50 mg / kg (42,4 ± 9,7) par rapport au témoin (170,0 ± 10,1) [p <0,05]. De même, 1,25 mg / kg de l’extrait réduit significativement le temps d’immobilité dans le TSQ (85,2 ± 8,9) par rapport au témoin (142,6 ± 3,9) [p <0,05] sans provoquer de modifications de l’activité motrice spontanée en champ ouvert. EEFAA a inversé la diarrhée, la ptose et l’hypothermie induites par la réserpine par rapport aux groupes témoins et n’a pas potentialisé la létalité induite par la yohimbine.
Conclusion: Il a été conclu que l’extrait a des propriétés antidépressives qui soutiennent son utilisation ethno-médicinale dans le traitement de la dépression.
Mots-clés: Immobilité, antidépresseur, Albizia adiantifolia, imipramine, reserpine
Correspondence: Dr. A.O. Aderibigbe, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria. E-mail: adebee738@yahoo.com; ao.aderibigbe@ui.edu.ng
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