Sažetak
Background: Adiponectin is a hormone produced mainly by adipocytes. The levels of adiponectin are inversely related to insulin resistance, hypertension and obesity. Physiological insulin resistance is exaggerated in pre-eclamptic women. The objective of the present study was therefore to compare serum adiponectin levels in pre-eclamptic patients and normotensive patients.
Methods: This prospective study was conducted among one hundred and twenty women. Purposive sampling technique was used to select all consenting participants, consisting of sixty pre-eclamptic patients as cases and sixty normotensive pregnant women at comparable gestational age as control. Concentration of serum adiponectin was measured by using enzyme linked immunosorbent assay (ELISA) method.
Results: Serum levels of adiponectin were significantly higher in the pre-eclampticgroup(p<0.001). Body mass index was also significantly higher in women with pre eclampsia (p<0.01).In the pre-eclamptic patients, serum levels of adiponectin showed a weak negative correlation with BMI (r= -0.16, p= 0.22) and no correlation was found in normotensive patients.
Conclusion: This study showed a clear distinction in the serum adiponectin concentration between preeclamptic and normotensive pregnant women. The impact of BMI on serum adiponectin in both groups also differs. Therefore, serum adiponectin may be useful in predicting pre-eclampsia.
Keywords: Serum adiponectin, Normotensive, pre-eclamptic, UCH, Pregnant woman
Résumé
Contexte: Adiponectine est une hormone produite principalement par les adipocytes. Les niveaux d’adiponectine sont inversement liés à la résistance à l’insuline, à l’hypertension et à l’obésité. La
résistance à l’insuline physiologique est exagérée chez les femmes pré-éclamptiques. L’objectif de la présente étude était donc de comparer les taux sériques d’adiponectine chez des patientes prééclamptiques et des patientes normo-tendues.
Méthodes: Cette étude prospective a été menée auprès de cent vingt femmes. La technique d’échantillonnage raisonné a été utilisée pour sélectionner tous les participants consentants, consistant soixante patientes pré-éclamptiques en tant que cas et soixante femmes enceintes normo-tendues à un âge gestationnel comparable en tant que témoin. La concentration d’adiponectine sérique a été mesurée en utilisant la méthode ELISA.
Résultats: Les taux sériques d’adiponectine étaient significativement plus élevés dans le groupe prééclamptique (p<0,001). L’indice de masse corporelle était également significativement plus élevé chez les femmes pré-éclamptiques (p <0,01). Chez les patientes pré-éclamptiques, les taux sériques d’adiponectine présentaient une faible corrélation négative avec l’IMC (r = -0,16 ; p = 0,22) et aucune corrélation chez les patientes normo-tendues.
Conclusion: Cette étude a montré une nette distinction dans la concentration sérique d’adiponectine entre les femmes enceintes pré-éclamptiques et normo-tendues. L’impact de l’IMC sur l’adiponectine sérique dans les deux groupes diffère également. Par conséquent, l’adiponectine sérique peut être utile pour prédire la pré-éclampsie.
Mots clés: Sérum adiponectine, normo-tendus, pré-éclampsie, UCH, femme enceinte
Correspondence: Dr. O.M. Akinpelu, Department of Obstetrics and Gynaecology, College of Medicine, University of Ibadan, Ibadan, Nigeria. E-mail:o_akinpelu@yahoo.com
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