Resumé
There has been a paucity of Nigerian studies on renal cell carcinomas (RCC). This retrospective review analyzes cases of RCC diagnosed in the University College Hospital, Ibadan from January 1960 to June 2007. Cases were typed using the 2004 World Health Organization classification of renal tumours. Papillary RCC were further grouped into Type 1 or 2 and Fuhrman’s nuclear grade was determined for clear cell and papillary RCC. There were 159 cases, 108 being females, with a male to female ratio of 1 : 2.1. Peak age of occurrence was in the fourth decade. The right kidney was more commonly affected (58.6%). Papillary RCC was the most common variant accounting for 27 of the 62 cases that were available for review. Six (22.2%) of the 27 papillary RCC had the distinctive histological features that have been associated with Xp11 translocation carcinoma. All 27 cases of papillary RCC were Type 2. Twenty-one (61.8%) RCC were Fuhrman’s nuclear grade 1 and 2. Renal cell carcinoma in Ibadan occurs two decades earlier than in Caucasians. Papillary RCC is the most common histological sub type of RCC in Ibadan, and Xp translocation carcinomas may be more common in this environment than earlier described in America. This is in contrast to the observation that clear cell carcinomas is the most common histological sub type of RCC in Caucasians series.
Keywords:- Renal cell carcinoma, Ibadan, Pathology.
Résumé
Cette revue rétrospective analysait les cas de RCC diagnostiqués au centre Universitaire Hospitalier, Ibadan de Janvier 1960 a Juin 2007. Les cas étaient examines utilisant la classification des tumeurs rénaux de l’Organisation Mondial de la Santé. Les RCC papillaires étaient plutôt de groupe en type 1 ou 2 et le grade nucléaire de Fuhrman était déterminé Pour les cellules propres e t les RCC papillaires. Ils y avaient 159 cas, 108 femelles, dans la proportion de femelle de 1 : 2.1. L’âge optimal était de quarante ans. Le rein droit était généralement le plus affecté (58.6%). Le RCC papillaire était le plus variant s’estimant 27 des 62 cas qui étaient disponible pour la revue. Six (22.2%) des 27 RCC papillaire avaient des caractéristiques distinctes histologiques qui ont été associés avec la translocation Xp11 carcinome. Tous les 27 cas de RCC papillaire étaient de type 2. Vingt-un (61.8%) des RCC étaient de type Fuhrman’s nucléaire de grade 1 et 2. Le carcinome cellulaire rénal à Ibadan apparait vingt ans avant que d’être chez les blancs. Le RCC papillaire est généralement le plus sous type de RCC histologique d’Ibadan, et la translocation Xp carcinomes peut être plus commun dans cette environnement plutôt que décrit en Amérique.
Correspondence: Dr. M.O. Odubanjo, Department of Pathology, University College Hospital, Ibadan, Nigeria.
Referencer
Landis SH, Murray T, Bolden S and Wingo PA. Cancer statistics: 1999. CA Cancer J Clin 1999; 49: 8–31.
Davey WW. Renal tumours in Nigeria. Br. J. Urol. 1964; 36: 340-346
Aghaji AE and Odoemene CA. Renal cell carcinoma in Enugu, Nigeria. West Afr. J. Med. 2000; 19:254-258.
Eke N, Egrudjakpor P., and Echem RC. Renal cell carcinoma presenting as a scalp swelling. Niger. J. Med. 2003; 12:154-156.
Seleye-Fubara D, Etebu E.N and Jebbin N.J. A Ten-Year Pathological Study of Renal Tumours in Port-Harcourt, Nigeria. Annals of African Medicine 2006; 5: 64-67.
Klufio GO. A review of genitourinary cancers at the Korle-Bu teaching hospital, Accra, Ghana. West Afr. J. Med. 2004; 23:131-134.
Elem B and Patil PS. Pattern of urological malignancy in Zambia. A hospital-based histopathological study. Br. J. Urol. 1991; 67:37-39.
Gueye SM, Diallo B, Fall PA, et al. Malignant kidney tumours in adults in Senegal: diagnostic and therapeutic problems. Dakar Med. 1998; 43:213-215.
Delahunt B and Eble JN. History of the development of the classification of renal cell neoplasia. Clin. Lab. Med. 2005; 25:231-246.
Delahunt B, and Eble JN: WHO histological classification of tumours of the kidney In: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Eble JN, Sauter G, Epstein JI, Sesterhenn I.A, Eds. I.A.R.C. Press, Lyon, 2004; pp. 10.
Chow WH, Devesa SS, Warren JL and Fraumeni JF Jr. Rising incidence of renal cell cancer in the United States. JAMA 1999; 281:1628–1631.
Castellanos RD, Aron BS and Evans AT. Renal adenocarcinoma in children: incidence, therapy and prognosis. J. Urol 1974; 111:534–537.
Chan HSL, Daneman A, Gribbin M and Martin DJ. Renal cell carcinoma in the first two decades of life. Pediatr Radiol 1983; 13:324–328.
Freedman AL, Vats TS, Stewart T, et al. Renal cell carcinoma in children: the Detroit experience. J Urol 1996; 155:1708–1710.
Asanuma H, Nakai H, Takeda M, et al. Renal cell carcinoma in children: experience at a single institution in Japan. J Urol 1999; 162:1402–1405.
Cangiano T, Liao J, Naitoh J, et al. Sarcomatoid renal cell carcinoma: Biologic behaviour, prognosis and response to combined surgical resection and immunotherapy. J Clin Oncol 1999; 17:523–528.
Störkel S, Eble JN, Adlakha K, et al. Classification of renal cell carcinoma: Workgroup no.1 Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Cancer 1997; 80:987–989.
Delahunt B and Eble JN: Papillary renal cell carcinoma In: World Health Organization |Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital organs. Eble JN, Sauter G, Epstein JI, Sesterhenn IA, Eds. I.A.R.C. Press, Lyon, 2004; pp 27-29
Delahunt B. Renal neoplasia WHO 2003. The increasing influence of molecular pathology. http://www.iap-aus.org.au/McGovern2003-B Delahunt. pdf.