Resum
A retrospective analysis of solid tumours in children less than 28days old over a 31year period (1978-2008) was carried out at University of Benin Teaching Hospital (UBTH) to determine the incidence and histological patterns of such tumours. A total of 17 cases were seen during the study period: 16 cases (9 in males and 7 in females) were benign and 1 was malignant and it was recorded in the male gender. Vascular tumours (n = 9), granular cell tumours (n = 4), teratomas (n = 2) and myxofibroma (n = 1) were the histological types of benign tumours seen. The only malignant tumour encountered was a rhabdomyosarcoma. Head and neck was the commonest location of the tumours and most cases presented within 2 weeks of birth.
Keywords: tumours, neonate, benign, malignant.
Résumé
Une analyse rétrospective des tumeurs solides chez les enfants de moins de 28 jours jusqu’ a la période de 31 ans (1978-2008) était évaluée au Centre Universitaire de l’état du Benin, Nigeria (UBTH) pour déterminer l’incidence et les fréquences histologiques de telles tumeurs. Au total, 17 cas étaient vus dans la période de cette étude: 16 cas (9 males et 7 femelles) étaient bénignes et un cas maligne, et était enregistré chez le gendre male. Les types histologiques des tumeurs bénignes vus étaient les tumeurs vasculaires (n = 9), tumeurs des cellules granulées (n = 4), tératomes (n = 2) et myxofibrome (n = 1). Le seul cas de tumeur maligne rencontré était le rhabdomyosarcome. La tête et le cou était la location le plus commune des tumeurs et les cas présentés dans les 2 semaines de naissances.
Correspondence: Dr. AP Igbe, PO Box 10189, Ugbowo, Benin City, Nigeria. E-mail: apijami @yahoo.com
Referències
Miatra A and Kumar V. Diseases of infancy and childhood: In Kumar V, Abbas AK, Fausto N, eds. Robbins and Cotran pathologic basis of disease. 7th ed. Philadelphia, WB Saunders Co, 2004; 469-508.
Campbell AN, Chan HS, O’Brien A, Smith CR and Becker LE. Malignant tumours in the neonate. Arch Dis Child. 1987; 62:19-23.
Broadbent VA. Malignant diseases in the neonate. In: Roberton NRC, ed. Textbook of neonatology. Edingburgh: Churchill Livingstone, 1986; 689-695
Barson AJ. Congenital neoplasia: the soceity’s experience. Paeditric Pathology Society. Arch Dis Child. 1978; 53: 436.
Bader JL and Miller RW. US cancer incidence and mortality in the first year of life. Am J Dis Child. 1979; 133: 157-159.
Davies CF, Carachi R and Young DG. Neonatal tumours: Glasgow 1955-86. Arch Dis Child. 1988; 63: 1075-1078.
Moore SW, Satge D, Sasco AJ, Zimmermman A and Plaschkes J. The epidemiology of neonatal tumours. Report of an international working group. Pediatr Surg Int. 2003; 19(7): 509-519.
Ekanem IA, Asindi AA, Ekwere PD, Ikpatt NW and Khalil MI. Malignant childhood tumours in Calabar, Nigeria. Afr J Med Sci 1992; 21(2): 62-69.
Schoen FJ. Blood Vessels. In: Kumar V, Abbas AK, Fausto N, eds. Robbins and Cotran pathologic basis of disease. 7th ed. Philadelphia, WB Saunders Co, 2004; 511-554.
Parkes SE. Neonatal tumours: a thirty-year population-based study. Med Pediatr Oncol. 1994; 22(5): 309-317.
Akyuz C, Kutluk T and Buyukpamukcu N. Solid tumours in the neonatal period. Clin Padiatr. 2003; 42(1): 29-34.
Abubakar AM, Ngadda HA and Chinda JY. Sacrococcygeal teratoma in Northeastern Nigeria: 18-year experience. Pediatr Surg Int. 2005; 21(8): 645-648.
Mohan H. Textbook of Pathology. New Delhi, Jaypee Brothers Medical Pub. LTD, 2005; 263-273
Lack EE, Worsham GF, Callihan MD, Crawford BE and Vawter GF. Gingival granular cell tumours of the newborn (congenital epulis): a clinical and pathologic study of 21 patients. Am J Surg Pathol. 1981; 5(1): 37-46.
Silva GCC, Vieira TC, Vieira JC, Martins CR and Silva EC. Congenital granular cell tumour (congenital epulis): a lesion of multidisciplinary interest. Med oral patol oral cir bucal (internet). 2007; 12(6).
Kupers AM, Andriessen P, van Kenpen MJ, van der Tol IG, Baart JA, Dumans AG and van der Waal I. Congenital epulis of the jaw: a series of five cases and review of literature. Pediatr Surg Int. 2009; 25(2): 207-210.
Moore SW, Kaschula ROC, Albertyn R, Rode H, Miller AJY and Karabus C. The outcome of solid tumours occurring in the neonatal period. Pediatr Surg Int. 1995; 10(5-6): 366-370
Mabogunje OA. Malignant childhood teratoma in the Nigerian savannah. Ann Trop Paediatr. 1985; 5(4): 201-205.
Amusa H B, Olabanji J K, Ogundipe O V et al. Pattern of head and neck malignant tumours in a Nigerian teaching hospital-A ten year review. West Afr J Med,2001; 23(4): 280-285.
Kumar V, Abbas AK and Fausto N, eds. Robbins and Cotran pathologic basis of disease. 7th ed. Philadelphia, WB Saunders Co, 2004; 269-342.
Bolande RP. Prenatal carcinogenesis (An Appraisal). Cancer. 1994; 74(6): 1674-1679.