The Pharmaceutical Properties, Microbial Quality, In-vivo Aphrodisiac Effect and Safety of Some Herbal Bitters Sold in Southwest Nigeria
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Keywords

Herbal Bitters
Pharmaceutical and microbial quality
aphrodisiac properties
safety

Abstract

Aphrodisiac drugs are used to enhance sexual activity and rectify erectile dysfunction especially among older men. In Nigeria, herbal medicinal products formulated as herbal drinks/bitters are prevalent and sold in various locations including motor parks, store and markets. Despite their wide use, the potency and safety of the herbal drinks have not been ascertained. Thus, pharmaceutical and aphrodisiac properties of five randomly selected herbal drinks with aphrodisiac claim have been evaluated. Pharmaceutical and microbial qualities were evaluated using standard procedures and the in vivo aphrodisiac activities were evaluated in male Wistar rats. The effects of chronic consumption of the bitters on the biochemical and tissue histology were assessed. The herbal bitters exhibited low viscosity (< 10 cP), high alcohol content (30 – 52 %), acidic pH (3.33 - 5.40), and low density (0.942-1.070 g/ml). The phytoconstituents include alkaloids, flavonoids, saponins, cardenolides, tannins and anthraquinone. Microbial contaminations were with the limits for oral preparations. The bitters exhibited significant (p < 0.001) aphrodisiac effect but had no significant effect on fertility and hematological parameters. Chronic consumption of the herbal drinks at 250mg/kg following was hepatotoxic while two brands were cardiotoxic and nephrotoxic. There is therefore the need to monitor and control the quality and use of herbal bitters/drinks sold in the Nigerian market to safeguard public health

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References

Agaba PA, Ocheke AN, Akanbi MO, Gimba ZM, Ukeagbu J, Mallum BD, Agaba EI. (2017): Sexual functioning and health-related quality of life in men. Niger Med J. 58: 96-100.

Ajala AS, Omobowale MO (2013): Paraga: Socioeconomic Context of the Production and Utilization of Alcoholic Herbal Remedy in Ibadan, Nigeria. Anthropos. 108 (1): 149-162.

Ariba AJ, Oladapo OT, Iyaniwura CA, Dada OA (2007): Management of erectile dysfunction: perceptions and practices of Nigerian primary care clinicians. SA Fam Pract 49 (9): 16-23.

Bodeker G, Kronenberg FA (2002): Public health agenda for traditional complementary and alternative medicine. Am J Public Health 92: 1582-1591.

Cao G, Yi T, Liu Q, Wang M, Tang S. (2016): Alcohol consumption and risk of fatty liver disease: a meta-analysis. Peer J. 4: e2633. Doi: 10.7717/peerj.2633

Cyriac S, Joseph L, Peethambaran PA, Narayanankutty K, Karthiayini K (2013): Semen quality characteristics of white Pekin, Kuttanad (Anas platyrhynchos domesticus) and Muscovy (Cairina moschata momelanotus) drakes. Indian J Animal Sci. 83(6): 595-599.

De Sousa Lima CM, Fujishima MAT, de Paula Lima B. (2020): Microbial contamination in herbal medicines; a serious health hazard to elderly consumers. BMC Complement Med Ther. 20: 17-21.

Du Plessis L, Soley JT (2011): Incidence, structure and morphological classification of abnormal spermatozoa in the emu (Domaius novaehollandiae). Theriogenol 75: 589-601.

European Pharmacopoeia (2007): Directorate for the quality of medicines of the council of Europe, 5th Edition. Strasbourg, France.

Fouche G, Afolayan AJ, Wintola OA, Khorombi TE, Senabe J (2015): Effect of the aqueous extract of the aerial parts of Monsonia angustifolia on the sexual behaviour of male Wistar rats. BMC 15:343.

Jequier AM. (2010): Semen analysis: a new manual and its application to the understanding of semen and its pathology. Asian J Androl. 12: 11-16.

Nahak AK, Giri SC, Mohanty DN, Mishra PC, Dash SK (2015): Effect of frequency of collection on seminal characteristics of white Pekin Duck. Asian Pac J Reproduc 4 (1): 70-73.

NIH (1993 a): Consensus Development Panel on Impotence. Impotence. JAMA. 270 (1):83-91

NIH (1993 b): NIH releases consensus statement on impotence. Am Fam Physic. 48(1): 147-150-163.

Oyelade BO, Abiodun C, Jemilohun AC, Aderibigbe SA (2016): Prevalence of erectile dysfunction and possible risk factors among men of South-Western Nigeria: a population-based study. Pan Afr Med J 24:124-129.

Oyeyemi MO, Babalola TE (2006): Testicular parameters and morphological characteristics of testicular and epididymal spermatozoa of White Fulani bulls in Nigeria. Int J Morphol 24:175–180.

Psaltopoulou T, Sergentanis T.N, Ntanasis Stathopoulos L. (2018): Alcohol consumption and risk of hematological malignancies: A meta-analysis of prospective studies. International J of Cancer 143 (3) 486-495.

Rowland D, Tai W (2003): A reviews of plant-derived and herbal approaches to the treatment of sexual dysfunction. J Sex Marital Ther. 29 (3): 185-205.

Sadovsky R, Nusbaam RM (2006): Sexual health inquiry and support is a primary care priority. J Sex Med 3 (1)3-11.

Shanley PF, Rosen MD, Brezis M, Silva P, Epstein FH, Rosen S (1986): Topography of focal proximal tubular necrosis after ischemia with reflow in the rat kidney. Am J Pathol. 122: 462–468.

Ugwumba FO, Okafor CI, Nnabugwu II, Okorie JC (2018) Prevalence of, and risk factors for erectile dysfunction in male type 2 diabetic outpatient attendees in Enugu, South East Nigeria. Ann Afr Med. 17 (4): 215–220.

Watcho P, Zelefack P, Nguelefack TB, Ngouela S, Telefo PB, Kamtchouing P, Tsamo E, Kamanyia A (2007): Effects of the aqueous and hexane extracts of Mondia whitei on the sexual behaviour and some fertility parameters of sexually inexperienced male rats. Afr J Trad Comple Alt Med. 4 (1): 37–46.

Wheeler NC, Andrews FN (1943): The influence of season on semen production in the domestic fowl. Poultry Sci 22: 361-67.

Wolfhagen FH1, Vermeulen HG, de Man RA, Lesterhuis W (2008): Initially obscure hepatotoxicity attributed to sildenafil. Eur J Gastroenterol Hepatol. 20 (7):710-20.

World Health Organization (2010): World Health Organization 5th ed. Geneva: WHO Laboratory Manual for the Examination and Processing of Human Semen.

World Health Organization (1998): Regulatory situation of herbal medicine: A worldwide review, World Health Organization, Geneva.

Yovwin DG, Imarrhiagbe FA, Obazee EM, Oguike TC. (2015): Erectile dysfunction in a sub-saharan African population: Profile and correlates in a tertiary care hospital. Sahel Med J. 18 (3): 116-120

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